By E.L. Cooper, A. Beschin, M. Bilej (editors)
This quantity first provides facts for the earthworm's immune method; the consequences strongly recommend that definite molecules of the earthworm's immune approach should be exploited as ordinary antibiotics - therefore the biomedical purposes. Earthworms have a powerful immune approach considering the fact that melanoma can't be brought about in them, nor does it appear to happen in average populations. Cytoxicity of melanoma cells has been tested relating to earthworm leukocytes established upon: constitution; mobile differentiation antigens; and serve as printed by means of FACS and mAbs.
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Additional info for A New Model for Analyzing Antimicrobial Peptides With Biomedical Applications (Nato: Life and Behavioural Sciences, 343)
Our study revealed that fraction 25 and 45 % Percoll gradient showing the highest cytotoxic activity were enriched with small and large cells. These data implicate basophils as the cell population responsible for target cell killing, analogous to mammalian NK activity as has been shown recently . 51Cr-release data from the Percoll fractions, in conjunction with percent cell population (Fig. 4) and cell size also suggest that the origin of NK-like activity in earthworms is from a unique stage of basophil development/differentiation corresponding with basophils of up to 16 um.
H. Kobayashi et al, Lethal and non-lethal responses of spermatozoa from a wide variety of vertebrates and invertebrates to lysenin, a protein from the coelomic fluid of the earthworm Eisenia foetida, J. Exp. Zool. 286 (2000) 538-549. H. Kobayashi et al, Toxicity of coelomic fluid of the earthworm Eisenia foetida to vertebrates but not invertebrates: probable role of sphingomyelin, Comp. Biochem. Physiol 128C (2001) 401-411. S. Lange et al, Interaction of earthworm hemolysin with lipid membranes requires sphingolipids, J.
S. 36 Hamed et al. / Cytochemical Properties Acknowledgments The authors express appreciation to volunteers from the Student Research Program: Steve Hsu, Hambik Oktanyan, Agnes Lau, Muni Yang, Lizbeth Miranda-Kuhn, Andrew Vuong and Andrew Kan, and Shinji Kasahara, Visiting Scholar in UCLA. We also thank Ms. Gwendolyn Hawkins, Department of Pathology and Laboratory Medicine, for her assistance in performing cytochemistry assays. References f 1]                          E.
A New Model for Analyzing Antimicrobial Peptides With Biomedical Applications (Nato: Life and Behavioural Sciences, 343) by E.L. Cooper, A. Beschin, M. Bilej (editors)