Download e-book for kindle: Advanced Nutrition - Micronutrients by Carolyn D. Berdanier

By Carolyn D. Berdanier

ISBN-10: 0849326648

ISBN-13: 9780849326646

Complicated foodstuff: Micronutrients, a continuation of the 1st complex foodstuff textual content on macronutrients, specializes in how nutrients function on the genomic point. It displays the main study endeavors by way of nutrients scientists through the global in learning nutrient-gene, nutrient-nutrient, and nutrient-drug interactions. The ebook is prepared in units-ideal for complicated undergraduate and graduate-level courses-as good as for examine. Unit 1 offers an outline of the consequences of micronutrients on human overall healthiness. Unit 2 discusses the combination of sensible facets of nutrients. the subsequent 3 devices, fat-soluble supplements, water-soluble supplements, and different natural foodstuff, supply vital information corresponding to:

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Enhancers: mechanisms of action and cell specificity, Annu. Rev. , 4:127. D. , Eds. 1993. Nutrition and Gene Expression, CRC Press, Boca Raton, FL, 579 pgs. R. 1993. Molecular advances in cardiovascular biology, Science, 260:916-917. F. Jr. 1992. The Vitamins, Academic Press, New York, 528 pgs. E. 1996. Mitochondrial genes as sites of primary action of steroid hormones, Steroids, 61:226-232. Derman, E. 1982. Transcriptional control in the production of liver specific mRNAs, Cell, 23:731-740. M.

431-454. A. 1987. Regulation of inducible and tissue specific gene expression, Science, 236:1237. L. 1994. Transcriptional regulation of gene expression: mechanisms and pathophysiology, Hum. , 3:180-199. G. and Vogt, D. 1990. Biochemistry, John Wiley & Sons, New York, pg. 771-986; 1086-1178. Yamamoto, K. 1985. Steroid receptor regulated transcription of specific genes and gene networks, Annu. Rev. , 19:209. © 1998 by CRC Press LLC UNIT 3 Fat-Soluble Vitamins TABLE OF CONTENTS I. Vitamin A A. Structure and Nomenclature B.

If dietary retinol (or its precursors) is lacking, serum RBP levels will fall while hepatic levels rise. Within minutes after retinol is given to a deficient individual, these changes are reversed: serum levels rise while hepatic levels fall. These observations provide clear evidence of the importance of this binding protein in the utilization of retinol. Compounds which influence the levels of this binding protein influence © 1998 by CRC Press LLC Table 4 Retinol Binding Proteins Acronym Protein Molecular Weight (Da) Location RBP Retinol binding protein 21,000 Plasma CRBP Cellular retinol binding protein 14,600 Cells of target tissue CRBP II Cellular retinol binding protein Type II 16,000 Absorptive cells of small intestine CRABP Cellular retinoic acid binding protein 14,600 Cells of target tissue CRALBP Cellular retinal binding protein 33,000 Specific cells in the eye IRBP Interphotoreceptor or interstitial retinol binding protein Nuclear retinoic acid receptor, 3 main forms (α, β, γ) 144,000 Retina RAR RXR All cells α — Liver β — Brain γ — Liver, kidney, lung Function Transports all- trans retinol from intestinal absorption site to target tissues Transports all- trans retinol from plasma membrane to organelles within the cell Transports all-trans retinol from absorptive sites on plasma membrane of mucosal cells Transports all- trans retinoic acid to the nucleus Transports 11- cis retinal and 11-cis retinol as part of the visual cycle Transports all-trans retinol and 11-cis retinal in the retina extracellular space Binds retinoic acid and regions of DNA having the GGTCA sequence Nuclear retinoic acid receptors, multiple forms the mobilization and excretion of retinol.

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Advanced Nutrition - Micronutrients by Carolyn D. Berdanier

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