By Juan Pablo Arroyo and Adam J. Schweickert (Auth.)
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Extra info for Back to Basics in Physiology Fluids in the Renal and Cardiovascular Systems. Distribution, Dynamics, and Regulation
The soldier was forced to maintain a static position for 12 h thus increasing the hydrostatic pressure within the veins and arteries of the lower limbs. ) By not being able to move and therefore inactivating the venous muscle pump, there was fluid accumulation within the capillaries, thus there was an increase in capillary hydrostatic pressure, which favored fluid leakage into the interstitial space (hence the edema). Example 2 A 7-year-old boy arrives to the emergency department with a 1 month history of generalized edema.
As R increases, flow decreases. And, flow is affected more strongly by a change in resistance than by an equal (but opposite) change in pressure. Ok, so why are we spending all this time talking about cars? Because the exact same principles hold true for blood flow! In the 1800s, a French physician named Louis Poiseuille observed this traffic phenomenon in blood flow. This guy had it all: looks, smarts, and a fancy name. In 1840, he formulated and published Poiseuille’s law. This law states that R 5 8nl/πr4, where R 5 resistance, n 5 viscosity of fluid, l 5 length of the blood vessel, and r 5 the radius.
When you dive to a certain depth, your ears feel like they’re about to explode! Why? Well, water is heavy. As you dive into the water, more and more water is above you. The pressure you feel is due to that water pushing down on you. Remember, pressure is force per unit area. All mass on earth experiences gravitational acceleration and therefore all mass exerts a force due to gravity. The larger the mass, the greater the force. Gravity is pulling the water in the pool/ocean, and everything else on our planet for that matter, toward the center of the earth.
Back to Basics in Physiology Fluids in the Renal and Cardiovascular Systems. Distribution, Dynamics, and Regulation by Juan Pablo Arroyo and Adam J. Schweickert (Auth.)