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33, p. 65, by permission of Oxford University Press. The M phase (comprising around 10% of the cell cycle duration) is divided into four phases on the basis of chromosome morphology and is the part during which nuclear division occurs (Fig. 5). Chromatin first condenses to reveal discrete chromosomes (prophase), after which the nuclear membrane disintegrates as the chromosomes align on the equator of the nuclear spindle (metaphase). The spindle is a fusiform structure composed of clusters of microtubules radiating from two centrioles at the poles of the cell.

38, p. 77, by permission of Oxford University Press. Gametes Chapter 2 Cellular, molecular, and membrane biology Nuclear 19 Basic Sciences for Core Medical Training and the MRCP 20 The maternal and paternal homologues then unite to form bivalents and there is genetic recombination as crossing over of segments of the chromosomes occurs. Bivalents align at the mitotic spindle and cell division (meiosis I) results in two daughter cells, containing a haploid number of chromosomes (each of which is a chromatid pair).

3 The glycolytic pathway. (a) The energy-investment phase. (b) The energy-generation phase, which only glyceraldehyde-3phosphate can enter. 21, p. 129, by permission of Oxford University Press. CoA, which can enter first the TCA cycle, and then electron transport chain to yield more energy by full oxidation; this complete/aerobic combustion of 1mol of glucose yields approximately 2870 kJ of energy. This is more the picture of metabolism expected in middle distance running, such as the 5-km distance.

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Basic Science for Core Medical Training and the MRCP by coll.

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