Read e-book online BCL2 Protein Family: Essential Regulators of Cell Death PDF

By Claudio Hetz

ISBN-10: 1441967052

ISBN-13: 9781441967053

During this e-book, scientists pioneering the sector have compiled a chain of concentrated chapters to spotlight the relevance of the BCL‑2 kinfolk of proteins in apoptosis, body structure and ailment. an enormous concentration of this quantity is thinking about the aptitude TH period PEUT IC merits of concentrating on apoptosis pathways within the context of human affliction. Readers drawn to knowing how a telephone handles tension and the implications of dysregulation of this procedure for human illness will locate this booklet very important. It makes an attempt to explain a desirable region of analysis the place body structure and biomedicine converge at assorted degrees, revealing a visit from the molecular rules of apoptosis to the effect of this method to the body structure of a complete organism.

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Extra resources for BCL2 Protein Family: Essential Regulators of Cell Death

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Homeostatic Functions of BCL-2 Proteins beyond Apoptosis 31 210. Iaquinta PJ, Lees JA. Life and death decisions by the E2F transcription factors. Curr Opin Cell Biol 2007; 19(6):649-657. 211. Altieri DC. The case for survivin as a regulator of microtubule dynamics and cell-death decisions. Curr Opin Cell Biol 2006; 18(6):609-615. 212. Lamkanfi M, Festjens N, Declercq W et al. Caspases in cell survival, proliferation and differentiation. Cell Death Differ 2007; 14(1):44-55. 213. Zinkel S, Gross A, Yang E.

Nat Cell Biol 1999; 1(5):298-304. 87. James DI, Parone PA, Mattenberger Y et al. hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem 2003; 278(38):36373-36379. 88. Labrousse AM, Zappaterra MD, Rube DA et al. C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell 1999; 4(5):815-826. 89. Mozdy AD, McCaffery JM, Shaw JM. Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p.

Acknowledgements The authors would like to thank Eric Smith for creation of figures and editorial assistance. References 1. Chipuk JE, Green DR. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol 2008; 18(4):157-164. 2. Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 2004; 116(2):205-219. 3. Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9(1):47-59. 4. Leber B, Lin J, Andrews DW.

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BCL2 Protein Family: Essential Regulators of Cell Death by Claudio Hetz

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