By Robert M. Berne MD, Bruce A. Stanton PhD
Lengthy revered for its scientifically rigorous procedure, this best-selling textual content now comprises significant updates to deliver you the entire most modern wisdom within the box. Honed and shortened to stress the center details wanted via scholars of body structure this day, it additionally includes a new full-color layout and all-new full-color paintings to augment clarity and increase your comprehension of each idea. With entry to the complete contents on-line at scholar seek advice, this wide-spread ebook supplies an in-depth figuring out of body structure extra powerfully and successfully than ever before.
- An organ system-based technique sincerely describes the entire mechanisms that keep watch over and control physically function.
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Additional resources for Berne and Levy Physiology: with STUDENT CONSULT Online Access, 6e
This deletion results in defective processing of the protein by the endoplasmic reticulum, and as a result the transporter does not reach the plasma membrane. , the epithelial Na+ channel [ENaC]). Thus, epithelial 33 / 1341 Berne and Levy Physiology, 6th Edition 34 / 1341 transport in individuals with cystic fibrosis is defective, which underlies the problems that these patients have. For example, in a normal lung the epithelial cells that line the airway are covered with a layer of mucus that entraps inhaled particulate matter and bacteria.
SGLT2 transports 1 glucose molecule with 1 Na+ ion, and the energy in the electrochemical gradient for Na+ (into the cell) is used to drive the secondary active uptake of glucose. Using the equation for calculating the electrochemical gradient, as rearranged below, and assuming a membrane potential (Vm) of -60 mV and a 10-fold [Na+] gradient across the membrane, an approximate 100-fold glucose gradient could be generated by SGLT2. 02 mmol/L. However, by increasing the number of Na+ ions transported with glucose from 1 to 2, SGLT1 can generate a nearly 10,000-fold glucose gradient.
The plasma membrane, with its hydrophobic core, is an effective barrier to the movement of virtually all of these biologically important solutes. It also restricts movement of water across the membrane. , O2 and CO2) and ethanol, which can diffuse across the lipid bilayer, movement of water and other solutes across the plasma membrane occurs via specific membrane transport proteins. Membrane Transport Proteins Table 1-2 lists the major classes of membrane transport proteins, their mode of transport, and the rate at which they transport molecules or ions across the membrane.
Berne and Levy Physiology: with STUDENT CONSULT Online Access, 6e by Robert M. Berne MD, Bruce A. Stanton PhD