By K. Pummer (auth.), Karl Pummer M.D. (eds.)
In the Sixties, it used to be suggested that interferons have antitumour job in several experimental types. seeing that that point, a variety of stories were played to clarify a few of the mechanisms of motion which have been proposed. despite the fact that, there's a lot controversy within the literature and promising preclinical findings did not translate into huge scientific development. the current publication offers a serious assessment of present wisdom of the way interferons act in strong tumours. For this goal, after chapters of common elements of interferon motion and interplay, chosen stable tumours that are regularly thought of tough to regard in complicated phases are mentioned with appreciate to either preclinical information and scientific experience.
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Extra resources for Biological Modulation of Solid Tumours by Interferons
IFN-alpha-2b .... ;,_ .. 60 ... ~ '. : 40 ................ Fig. 1. 1 mg/ml), interferon-~ (10 to 1,000 IUlml), interferon-a2a/2b (10 to 1,000 IUlml), and untreated control 20 ....... tg/ml) Richtsmeier et al.  assessed the antineoplastic effect of IFN-y by the loss of cell protein mass by staining cultures with naphtol blueblack dye. The epidermoid carcinoma cell lines JHU-011, SCC-L-P, UM-SCC-16, and A431 were tested, and long-term treatment up to 4 days appeared to be an important factor for the generation of cytotoxic effects.
The effectiveness of surgery and/or radiation therapy in curing patients with head and neck cancer is well established. These therapeutic measures have resulted in satisfactory survival rates for locally confined tumours with absent or only minor lymph-node metastasis. However, despite radical surgery combined with major plastic functional reconstruction and the development of refined radiotherapeutic techniques, the prognosis of advanced head and neck cancer remains poor. After initial treatment of resectable stage III and IV disease, 50% to 60% of patients have locoregional reccurence and 15% to 25% develop distant metastases.
Samonigg active regimen against advanced colon cancer. J Clin Oncol 1989 (7):1769-1775 pazdur R, Ajani JA, Patt YZ, et al: Phase II study of fluorouracil and recombinant interferon alfa-2a in previously untreated advanced colorectal carcinoma. J Clin Oncol1990 (8):2027-2031 Gresser I, Bourali C, Levy JP, Brouty-Boye 0, Thomas MT: Increased survival in mice inoculated with tumor cells and treated with interferon preparations. Proc Natl Acad Sci USA 1969 (63):5157 Gresser I, Bouraly C: Antitumor effects of interferon preparations in mice.
Biological Modulation of Solid Tumours by Interferons by K. Pummer (auth.), Karl Pummer M.D. (eds.)