Biologically Active Natural Products: Pharmaceuticals - download pdf or read online

By Stephen J. Cutler, Horace G. Cutler

ISBN-10: 0849318874

ISBN-13: 9780849318870

ISBN-10: 1420048651

ISBN-13: 9781420048650

Biologically energetic normal items: prescribed drugs demonstrates the connections among agrochemicals and prescribed drugs and explores using vegetation and plant items within the formula and improvement of prescribed drugs. specialists from around the globe research a mess of subject matters, together with evaluate of extracts from tropical crops for capability anticancer task and melanoma chemopreventive task; use of chinese language lacquer tree sap items as pharmaceutical intermediates; and new techniques to drug discovery from the rainforest.

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2000 by CRC Press LLC  References 1. , Econ. , 38, 4-13, 1977. 2. , and Guo, Z. Bull. , 63(6), 965-981, 1985. 3. , in Biodiversity and Human Health, Grifo, F. , 1997, 131. 4. W. , Primates, 24, 276-282, 1983. 5. , Experientia, 41, 419, 1985. 6. , Cancer Treat. , 60, 987, 1976. 7. S. , Academic Press, San Diego, 1992, 119. 8. F. , Columbia University Press, New York, 1996, 74-87. 9. J. , Ciba Foundation Symposium 154, Wiley, Chichester, 1990, 22-29. 10. J. , Ciba Foundation Symposium 154, Wiley, Chichester, 1990, 22-39.

Although the size of each circle is drawn arbitrarily, it is nevertheless a plain fact that there are significant areas of nonoverlap, and that all three approaches are needed to ensure the discovery of as many new pharmaceuticals as possible. 4 Natural Products Can Provide Templates for Future Drug Design In many cases the isolated natural product may not be an effective drug for any of several possible reasons, but it may nevertheless have a novel pharmacophore. In such cases chemical modification of the natural product structure, either by direct modification of the natural product (semisynthesis) or by total synthesis, can often yield clinically useful drugs.

Of Families Families Collected Families Collected (%) No. of Genera Genera Collected Genera Collected (%) Ferns Gymnosperms Monocots Dicots 35 7 47 204 11 6 23 150 31 86 49 74 95 9 494 2069 14 6 84 898 15 67 17 43 Total 293 190 65 2667 1002 38 Taxon of them. Therefore, given that collecting has been restricted to five countries in tropical Africa, the fact that 13 families of ferns, 1 gymnosperm family, 10 monocot families, and 34 families of dicots with only a single genus in the area remain uncollected is not surprising.

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Biologically Active Natural Products: Pharmaceuticals by Stephen J. Cutler, Horace G. Cutler


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