By W.-H. Boehncke (Editor), H.H. Radeke (Editor)
This can be the 1st ebook to hide each perspective within the medical software of biologics. Readers won't in basic terms locate that each one of the biologics at the moment licensed for medical use are delineated in a standardized manner, but additionally the "differential treatment" with biologics in fields together with dermatology and neurology is defined intimately and summarized in remedy algorithms. Shorter sections on biologic biotechnology in addition to safeguard and regulatory concerns supplement the extra clinically-oriented significant chapters.
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Additional info for Biologics in General Medicine
Ann Rheum Dis 62(Suppl 1):170 (poster THU0201) Keystone E, Haraoui B, Bykerk VP (2003c) Role of adalimumab in patients with early versus late rheumatoid arthritis (RA) [abstract]. Clin Exp Rheumatol 21(5 Suppl 31):S198–S199 Keystone ED, Kavanaugh AF, Sharp JT, et al. (2004a) Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy. Arthritis Rheum 50:1400 – 1411 Keystone ED, Kavanaugh AF, Sharp JT, et al.
08/100 PYs). Six of these were cases of multiple sclerosis (MS) (Schiff et al. 2006). This rate is consistent with the background rate of MS in society as a whole and with that of other TNF inhibitors. The literature suggests that patients with MS have a statistically significantly higher coexistence of RA, psoriasis, and goiter than matched controls (Heinzlef et al. 2000). Patients with RA and Crohn’s disease who develop neurologic signs after exposure to TNF inhibitors may innately be at increased risk of developing MS as compared with the general population (Magnano et al.
7 years. The coprimary efficacy endpoints compared combination therapy with MTX monotherapy with regard to proportion of patients who achieved an ACR50 response and the mean change from baseline in modified TSS. 2). 001) (Fig. 4a). This trend also was observed for ACR20, 70, and 90 response rates 70 Patients (%) 60 * 62 * 59 50 46 41 40 43 37 Year 1 Year 2 30 20 10 0 a Adalimumab + MTX Adalimumab MTX b Fig. 4. Results from the PREMIER study: a American College of Rheumatology 50 (ACR50) response at years 1 and 2.
Biologics in General Medicine by W.-H. Boehncke (Editor), H.H. Radeke (Editor)