Download PDF by S. Dhein: Cardiac Gap Junctions: Physiology, Regulation,

By S. Dhein

ISBN-10: 3805565674

ISBN-13: 9783805565677

An important verbal exchange mechanism among cardiac cells is electric transmission through low resistance pathways, the so-called hole junction channels. This booklet offers a entire evaluate of what's identified approximately cardiac hole junctions. An creation into a few of the elements of activation propagation and coupling within the middle is via a close description of the constitution and variety of hole junctions, together with amino acid sequences and species variability. next chapters speak about their distribution, body structure and services and the law of expression. the writer then is going directly to placed those easy findings right into a scientific context - the alterations of hole junction distribution during cardiac disorder and their implications. one other bankruptcy offers pharmacological methods to the modulation of hole junction channel conductivity and descriptions attainable healing techniques. the ultimate a part of the booklet describes the equipment of research together with double mobile voltage clamp, immunohistochemistry, isolation tactics for hole junctions and dye coupling assays.

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Extra resources for Cardiac Gap Junctions: Physiology, Regulation, Pathophysiology and Pharmacology

Sample text

1991]. In accordance with this finding, Oosthoek et al. [1993a] could not detect Cx43 expression in human or bovine AV-nodal tissues. However, besides Cx40 Davis 3 Distribution of Gap Junctions in the Heart 29 et al. [1995] did find some Cx43 and Cx45 in human AV node. The reason for this discrepancy is not yet known. Since, however, van Kempen et al. [1995] could show that the connexin distribution patterns are to a large extent comparable between various mammalian species, these data taken together show that Cx40 is probably the predominant connexin in the AV node, and Cx43 plays only a minor role.

1991]. However, in the heart, Cx40 and low levels Cx45, Cx43 is found most abundantly. The distribution of the various connexins exhibits a specific pattern with some species variability which will be discussed in the next section. Cx43 has been detected in many areas of the heart; however, only very low levels were found in AV node and sinus node. Cx43 was absent in AV 3 Distribution of Gap Junctions in the Heart 27 Fig. 10. Photomicrograph demonstrating immunohistochemical staining for Cx43 in cryostat sections of the left ventricle of the rat heart.

The lower figure gives the corresponding phase contrast microphotograph. 3 Distribution of Gap Junctions in the Heart 32 Fig. 12. Drawing of the distribution of various connexin isoforms within the vascular wall. Presently it is not certain whether gap junctions between endothelial and smooth muscle cells exist in the vascular wall. Such myoendothelial interconnections could be an interesting mechanism of signal transduction from the lumen or the endothelium to the media and might also contribute to upstream regulation of vascular tone, but, although theoretically anticipated, they have not been shown unequivocally until now.

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Cardiac Gap Junctions: Physiology, Regulation, Pathophysiology and Pharmacology by S. Dhein

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