By Philip K. Moore, Matt Whiteman
This booklet places hydrogen sulfide in context with different gaseous mediators reminiscent of nitric oxide and carbon monoxide, studies the to be had mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a large choice of affliction states. Hydrogen sulfide has lately been came upon to be a obviously happening gaseous mediator within the physique. Over a comparatively brief time period this evanescent gasoline has been published to play key roles in a variety of physiological strategies together with keep watch over of blood vessel quality and therefore blood strain and within the legislation of nerve functionality either within the mind and the outer edge. problems in regards to the biosynthesis or task of hydrogen sulfide can also predispose the physique to ailment states comparable to irritation, cardiovascular and neurological problems. curiosity during this novel fuel has been excessive lately and lots of learn teams around the world have defined its person organic results. in addition, medicinal chemists are commencing to synthesize novel natural molecules that unlock this fuel at outlined premiums as a way to exploiting those new compounds for healing benefit.
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Extra resources for Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide
3 Reaction with Disulfides . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Nonenzymatic S-sulfhydration by Species Originating from H2S . . . . . . . . . . 1 Reaction with Polysulfides . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Reaction with Metal Centres and Generation of HS• . . . . . . . . . . . . 3 “Trans-persulfidation” by Polythiolated Cysteine or Glutathione . . . . . .
0041147 Zhang G, Wang P, Yang G, Cao Q, Wang R (2013) The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma. Am J Pathol 182:1188–1195. 008 Zhao W, Zhang J, Lu Y, Wang R (2001a) The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener. EMBO J 20:6008–6016 Zhao W, Zhang J, Lu Y, Wang R (2001b) The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J 20:6008–6016. 6008 Zhou Y, Yu J, Lei X, Wu J, Niu Q, Zhang Y, Liu H, Christen P, Gehring H, Wu F (2013) Highthroughput tandem-microwell assay identifies inhibitors of the hydrogen sulfide signaling pathway.
Filipovic controlling the protein function has been extensively reviewed elsewhere (Hess and Stamler 2012; Seth and Stamler 2011). The mechanism of protein S-nitrosation is still the matter of debate (Broniowska and Hogg 2012). Like in the case of S-sulfhydration, direct reaction of NO with thiols to lead to the S-nitrosothiol formation is thermodynamically unfavourable. The mechanism usually involves either the reaction of thiols with higher nitrogen oxides, such as N2O3, or reactions with metal centre-catalysed one-electron oxidation product of NO (Broniowska and Hogg 2012).
Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide by Philip K. Moore, Matt Whiteman