By R. J. Schnitzer
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Additional resources for Chemotherapy of Bacterial Infections
Pergamon Press, London. Beckwith, T. D. (1921). Studies on the chemotherapy of the experimental typhoid carrier condition. / . Infectious Diseases 29, 495-512. Bennett, C , Blacklock, J. W. , and Browning, C. H. (1922). The action of flavine antiseptics on localized pyogenic infections, with special reference to the processes of healing. Brit. Med. J. I I , 306-309. , and Carrie, C. (1933). Zur Pharmakologie des Trypaflavins. Dermatol Z. 66, 330-335. Blacklock, J. W. S. (1929). The effect of flavine antiseptics on tissue growth in vivo.
H. BROWNING conjunctiva and cornea respond to brief contact with proflavine ( 2 % ) and acriflavine ( 0 . 6 6 % ) only with transient congestion. 025% is unlikely to damage the epithelium of urethra, cornea, or the peritoneal lining. Carcinogenesis has not been observed after prolonged application to the skin of mice (Kennaway; see Browning, 1937), but allergy might develop after repeated contact with wounds over a time (Young and Hawking, 1938; Sneddon, 1946). b. Connective Tissue, Muscle, and the Process of Wound Healing.
Caused disappearance of spirilla from the blood for 3 to 12 days in 10 animals. The corresponding styryl compound, which has — C H = H C — instead of the anil link, in a nearly maximal dose had no therapeutic effect. A number of analogous anils and styryls mostly were inactive. However, these results demonstrated for the first time antispirillar action produced by synthetic products which contained neither metals nor metalloids. Various anils and styryls are trypanocidal in vivo for T. brucei (see Hawking, Vol.
Chemotherapy of Bacterial Infections by R. J. Schnitzer