By Elaine Swan
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Additional resources for Colorectal cancer
2001). However, a link has been shown between obesity and adenoma development. The ability of individuals to use energy efﬁciently may inﬂuence the increased risk of cancer associated with overeating. Thus, the risk of colorectal cancer development may be lower in those individuals with a more efﬁcient metabolism. Smoking The effect of smoking on the development of colorectal cancer is unclear and indeed the effect of the interaction between smoking and alcohol on the development of cancer is hard to separate.
Surveillance for women in families where mutations are not known is difﬁcult to assess, particularly where gynaecological tumours are obvious in the family tree. Other surveillance Dependent on the family history, other cancer surveillance may be recommended, such as urological or gastric surveillance. CAPP 2 CAPP 2 is an ongoing trial to ascertain the effect of aspirin and starch on the development of polyps in patients who have HNPCC and/or are mutation carriers. Patients undergoing treatment for cancer are excluded initially.
Surveillance is recommended and colectomy may be advised. 3 Mutation-positive family. APC, adenomatous polyposis coli; FAP, familial adenosis polyposis; HPNCC, hereditary non-polyposis colon cancer I: 1 II: 1 II: 2 Lucy Waring One-off colonscopy arranged at time of daughter’s diagnosis II: 3 Sydney Preston 58 Ca Lung III: 1 Dennis Granger IV: 3 Peter Granger 2 Feb 1951 IV: 4 Sally Collins 11 Dec 1946 Not an APC faulty gene carrier Not yet tested Having regular bowel surveillance No further bowel surveillance required I: 2 IV: 6 Sporadic cancer III: 2 Florence Granger IV: 5 Jacqueline Lewis 24 Apr 1957 FAP diagnosed age 31 V: 3 Robert Lewis V: 4 Vicky Waring 19 Does not carry faulty APC gene 21 Carries faulty APC gene IV: 1 Robert Granger 2 Jan 1944 IV: 2 58 Not a faulty gene carrier V: 1 David Granger V: 2 Amy Granger 30 28 Annual bowel surveillance required Prophylactic surgery recommended Colorectal cancer: epidemiology and genetics 43 Recessively inherited colorectal cancer (MYH/MAP) An inherited bowel cancer syndrome called MYH associated polyposis or MAP has recently been discovered.
Colorectal cancer by Elaine Swan